What should I do if my transmission is making pulsing sounds when driving with rear windows down?
The vehicle aerodynamics are designed to improve fuel economy performance, which may cause a pulsing sound when either rear window is down and the front windows are up. To reduce this sound, open a front window or operate the sunroof if equipped. (Page 31)
From the official Chevrolet Trailblazer manual, page 31
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