What are the acceptable temperature ranges for this thermostat?

The acceptable temperature ranges are: Heat setting must be 40° to 90°F (4.5° to 32°C), and Cool setting must be 50° to 99°F (10° to 37°C). If temperature settings are not changing, ensure they are configured within these ranges.

From the official Honeywell Focuspro TH5220D Thermostat manual, page 5

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