Does the TH8320U1008 thermostat contain any hazardous materials I should be aware of?

Yes, the thermostat contains a Lithium battery which may contain Perchlorate material. Perchlorate material may require special handling, and you can find more information at www.dtsc.ca.gov/hazardouswaste/perchlorate. (Page 1)

From the official Honeywell Th8320U1008 Thermostat manual, page 1

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