How often should I descale my Keurig K-Supreme Plus, and how do I do it?

You should descale the brewer every 3 months or when the descale notification turns on. To begin, pour the entire bottle of Keurig Descaling Solution into an empty water reservoir, fill the empty bottle with water and add it to the reservoir, then activate Descale Mode by pressing and holding the 8oz and 12oz buttons together for 3 seconds with the brewer plugged in and powered off. Follow the full descaling and fresh water rinse steps until the DESCALE notification turns off, which takes approximately 15-20 minutes. (Page 10-11)