How often should I run the coffee circuit cleaning program, and how long does it take?

You should run the cleaning program after approximately every 360 preparations of espresso or coffee, and the appliance will periodically display a message when it is time. The full cleaning program takes approximately 20 minutes and is divided into three parts: the cleaning cycle itself, followed by two rinsing cycles. You will need a container with a capacity of at least 20 oz and a KRUPS XS 3000 cleaning tablet. (Page 10)

From the official Krups Ea81 Series Espresseria Automatic Coffee Machine manual, page 10

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