What should I do if the system becomes unstable or fails to boot after changing BIOS settings?

If the system becomes unstable after a BIOS change, load the default settings by selecting Load Optimized Defaults under the Exit menu or pressing the F5 hotkey to ensure system compatibility and stability. If the system fails to boot, try clearing the CMOS to reset the motherboard to its default values. ASUS strongly recommends only changing BIOS settings with the help of trained service personnel.

From the official ASUS Prime B660 Plus D4 Motherboard manual, page 26

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