How do I factory reset the Honeywell FocusPro TH5220D thermostat?

Press and hold the 's' button and the 'Fan' button until the display changes to indicate a setup mode. This process clears all settings and returns the device to its initial factory state. You will need to reconfigure all preferred settings after reset. (Page 6)

From the official Honeywell Focuspro Th5220d manual, page 6

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