How do I set up the HPA8350 for first use?

Before using your new air purifier, you must remove the wrappers covering the filters and pre-filter. Make sure the air purifier is OFF and unplugged, press the two hand symbols on the front grille to release it, remove the filters, unwrap them, and reinstall them with the pull tabs facing outward. Replace the front grille, plug the unit in, and tap the Power button to turn it on. (Page 3)

From the official Honeywell HPA8350 Air Purifier manual, page 3

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