How can I lock the volume control to one specific device?

Press and hold SETUP until the LED blinks twice, then enter 993. Press the device button you want to always control the volume (such as TV), and the LED will blink twice. Now the VOL +, VOL -, and MUTE buttons will only control that device regardless of what other device you're controlling.

From the official Insignia Universal Remote TV manual, page 13

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