How do I set up my remote using the SimpleSet method?

Turn on your device and point the remote at it. Press the device button you want to set up, then press and hold SETUP until the LED blinks twice. Press and hold the number button corresponding to your device brand from the SimpleSet tables. Release the button when your device turns off, and the LED will blink twice to confirm setup.

From the official Insignia Universal Remote TV manual, page 11

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