How do I program channel shortcut macros on the colored buttons?

Select the device you use to watch live TV, then hold down SETUP and the colored button (for example red for sports) until the LED blinks twice. Enter channel numbers one at a time, pressing and releasing the colored button between each entry. After entering all channels, hold SETUP until the LED blinks twice. You can program up to 10 different channel numbers per button.

From the official Insignia Universal Remote TV manual, page 14

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