How do I set up my Keurig K-Duo for the first time?

Remove packing tape and plug the coffee maker into an outlet. Rinse the carafe and place it on the heating plate. Remove the water reservoir, fill it with fresh water to the MAX fill line, and replace it ensuring the lock tabs engage. Press the POWER button, then use the H/M buttons to set the clock and press the blinking brew button to confirm the time. The clock must be set to use Auto Brew functionality. (Page 2)

From the official Keurig K-Duo Dual Brew Coffee Maker manual, page 2

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