What should I do if there is an F21 drain problem error?

Select PAUSE/CANCEL twice, unplug the washer or disconnect power. Check for kinks, freeze and blockages in the drain hose; ensure it isn't located more than 96 inches above the floor level. Reconnect power and select your cycle after addressing issues; if problem continues, seek service (Page 23)

From the official Whirlpool Duet Front Load Washer manual, page 23

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